AKR7A2 CLIA Kit for Human(Homo sapiens) | EIAab.comAKR7A2 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > AKR7A2(Gene name) > Human

AKR7A2 (Gene name),

Aflatoxin B1 aldehyde reductase member 2 (Protein name ), ARK72_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AKR7A2(AFAR;AFAR1;AKR7);

Protein name:

Aflatoxin B1 aldehyde reductase member 2;

Alternative:

Aldoketoreductase 7;AFB1 aldehyde reductase 1(AFB1-AR 1);Succinic semialdehyde reductase(SSA reductase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Subcellular Location:

Golgi apparatus Cytoplasm

Protein Attributes:

Sequence length:

359

Sequence:

50:

100:

150:

200:

250:

300:

350:

359:

AHECPNYFR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8574

String:

O43488

STRING:

9606.ENSP00000235835

MIM:

603418

Pfam:

PF00248

UniGene:

Hs.571886

SMR:

O43488

Uniprot:

O43488

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ELISA Kit for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

E15236h

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96T

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ELISA Kit for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

E15236m

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96T

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ELISA Kit for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

E15236r

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96T

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CLIA Kit for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

U15236r

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

U15236m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

U15236h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

P15236Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

P15236Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Aflatoxin B1 aldehyde reductase member 2

Cat.:

P15236Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Aflatoxin B1 aldehyde reductase member 2

Protein for Human Aflatoxin B1 aldehyde reductase member 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-359
tissue: Pancreas.
tissue: Skin.
tissue: Uterus.
3.

"Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase."
Ireland L.S. , Harrison D.J. , Neal G.E. , Hayes J.D.
Biochem. J.332:21-34(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-359;PARTIAL PROTEIN SEQUENCE;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT THR-142
tissue: Liver.
4.

"Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells."
Praml C. , Savelyeva L. , Perri P. , Schwab M.
Cancer Res.58:5014-5018(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-359
tissue: Brain.
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-359
6.

Lubec G. , Vishwanath V.
Submitted (2007-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 222-236; 251-261 AND 279-297;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
7.

"Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members."
O'Connor T. , Ireland L.S. , Harrison D.J. , Hayes J.D.
Biochem. J.343:487-504(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
8.

"Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins."
Kelly V.P. , Sherratt P.J. , Crouch D.H. , Hayes J.D.
Biochem. J.366:847-861(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
9.

"Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2."
Lyon R.C. , Johnston S.M. , Watson D.G. , McGarvie G. , Ellis E.M.
J. Biol. Chem.282:25986-25992(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Structure of the aflatoxin aldehyde reductase in complex with NADPH."
Structural genomics consortium (SGC)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH NADP
12.

"Genetic variation of aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells."
Praml C. , Schulz W. , Claas A. , Mollenhauer J. , Poustka A. , Ackermann R. , Schwab M. , Henrich K.-O.
Cancer Lett.272:160-166(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-142 AND HIS-157

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